Leukemia 2


How would the transition from normal B cells to leukemic cells via antigen stimulation occur? Normal B lymphocytes using unmutated IgV genes produce antibodies that are frequently polyreactive, binding carbohydrates, nucleic acids and phospholipids. Such antibodies provide the first line  of defense against microorganisms and promote the clearance of autoantigens and their fragments. B-CLL cells frequently display polyreactive BCRs, thereby making it possible that they derive from normal polyreactive B lymphocytes that have been repeatedly stimulated in vivo by a combination of nonprotein self and microbial antigens.

About azaleaazelia

A nice person... :)
This entry was posted in Tak Berkategori. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s