Immunological aspects of immunodeficiency diseases part 99

Immune 3

 

The key event in complement activation is the proteolytic cleavage of C3 to C3a and C3b. Three pathways can lead to C3 cleavage, namely, classical, alternative, and mannose-binding lectin (MBL) pathways. C3 cleavage leads on to the activation of the terminal complement pathway, causing the generation of the membrane attack complex (MAC), which assembles a lipophilic complex capable of lysing plasma membranes of susceptible cells.

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1 Response to Immunological aspects of immunodeficiency diseases part 99

  1. Dan Kempfer says:

    I do agree with all of the ideas you have presented in your post. They’re really convincing and will certainly work. Still, the posts are too short for newbies. Could you please extend them a little from next time? Thanks for the post.

    Like

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